High Doses of Biotin in Chronic Progressive Multiple Sclerosis

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High Doses of Biotin in Chronic Progressive Multiple Sclerosis

Among hypotheses that tend to explain the cause(s) of progressive MS, it has been proposed that progressive degeneration could be linked to a phenomenon of “virtual hypoxia” caused by a mismatch between increased energy demand by the demyelinated axon and decreased energy production because of mitochondrial injury. No drug has been found to have any impact on progressive multiple sclerosis (MS).

Biotin is a vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetyl CoA carboxylase, a potentially key regulating enzyme in myelin synthesis.  The aim of a pilot study was to assess the clinical efficacy and safety of high doses of biotin in patients suffering from progressive MS. Twenty-three consecutive patients with primary and secondary progressive MS who originated from three different French MS reference centers were treated with high doses of biotin (100–600 mg/day; median 300 mg/day in 3 divided doses) from 2 to 36 months (mean=9.2 months). Judgement criteria varied according to clinical presentations and included quantitative and qualitative measures.

In four patients with prominent visual impairment related to optic nerve injury, visual acuity improved significantly. Visual evoked potentials in two patients exhibited progressive reappearance of P100 waves, with normalization of latencies in one case. Proton magnetic resonance spectroscopy (H-MRS) in one case showed a progressive normalization of the choline/creatine ratio. One patient with left homonymous hemianopia continued to improve from 2 to 16 months following onset of treatment. Sixteen patients out of 18 (89%) with prominent spinal cord involvement were considered improved as confirmed by blinded review of videotaped clinical examination in 9 cases. In all cases, improvement began 2 to 8 months after starting treatment.

  • Biotin activates enzymes involved in energy production and myelin synthesis.
  • 91.3% of SPMS or PPMS patients improved clinically with high doses of biotin.
  • Improved conditions included chronic optic neuropathy, homonymous hemianopia or myelopathy.
  • In all cases improvement was delayed from 2 to 8 months following treatments onset.
  • These preliminary data suggest that high doses of biotin might have an impact on disability and progression in progressive MS.
  • Two multi-centric double-blind placebo-controlled trials are currently underway.



Multiple Sclerosis and Related Disorders. March 2015; 4(2):159–169

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About Dr. Jenny:

Dr. Jenny is a Naturopathic Doctor and clinical research associate. She is a successful entrepreneur as the CEO/Proprietor of AgeVital Pharmacies in Sarasota, Florida. She is a charismatic media personality and television producer with regular appearances on ABC, NBC, TBN, CBS, the CW and up coming show on Lifetime. As a health and wellness expert and educator, Dr. Jenny lectures all around the world at various conferences about the endocannabinoid system and functional integrative healthcare and how natural solutions work to treat a multitude of disease and illness. She is currently authoring books about the endocannabinoid system for healthcare practitioners and consumers.
She is the President and Chairman of The American Academy of the Endocannabinoid System (AAECS) and sits on the Executive Board of Directors for the American Board of Medical Marijuana Physicians (ABMMP)Her expansive credentials include a Board Certification at The American Board of Anti-Aging Health Practitioners – (ABAAHP), a Diplomate of the AAIM College of Nutrition and a Board Certification with the (AAIM) Board of Integrative Medicine. Dr. Jenny is also a member of the American Academy Of Anti-Aging Medicine, serves as a senior business and financial advisor for Nuvusio and the medical director for Biom-Pharmaceuticals and Chief Scientific Officer And Medical Director for M3. 
*Results may vary. Information and statements made are for education purposes and are not intended to replace the advice of your doctor.  The views and nutritional advice expressed by AgeVital Pharmacy are not intended to substitute for medical service. If you have a severe medical condition or health concern, see your physician or give us a call and schedule a consultation with one of our providers. ©AgeVital Pharmacy


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